Oriental Mindoro, located 140 kilometers southwest of Manila, is only 45 minutes by air-conditioned ferry ride from the International Port of Batangas. It can also be reached via air in 30 minutes from NAIA Domestic Airport.

Oriental Mindoro is bounded on the north by the Verde Island Passage, on the east by Maestro del Campo Island and the Tablas Strait, on the south by Semirara Island in the west by the province of Occidental Mindoro.